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The men were randomised to Weight Watchers weight loss programme plus placebo versus the same weight loss programme plus testosteroneor placebo. The placebo group maintained 1.7kg more weight than the weight lost by the men on the weight-loss programme plus testosterone, and the weight-loss programme plus testosterone group maintained 1.6kg more weight than those on the placebo programme. There were no significant differences in body weight or fat between the groups. The women, who were randomised to the placebo or to the testosterone programme at the weight-loss clinic, maintained weight over the 12 weeks, compared with 1.7kg for the men on the placebo programme, at a mean difference of −0.5kg in weight (95% confidence interval [CI] −1.6 to −0.3 kg; Fig 1 ). There were no significant differences in weight differences with the testosterone programme in the other age ranges, BMI, weight gain or percentage weight loss for either group. Weight loss to the mean of the weight gained as a proportion of baseline weight (i.e. −0·6 or −2·6% or −3·2%) was obtained for 6·6% of the women and 10·7% of the men on the placebo intervention (Fig 2 ), and for 7·4% and 2·1% on the weight loss programme (Fig 3 ). There was no change in weight loss between the women and men on either weight loss programme over the 12 weeks. There were no significant differences in the weight-loss-induced increase in the percentage of body fat of the male or female participants after 12 weeks, compared with baseline. For both groups, the mean percentage change was 1·3±0·6%. All these weights were significantly smaller than the mean weight loss achieved by the men on either weight-loss programme at 0·8kg (0·6·1, −0·5) (P<0·05) or 4·3kg (3·1·9, −4·5) (P< 0·05)]. There were no significant differences in mortality between the groups. The weight gain during the 12 weeks of the treatment was significantly greater (P<0·04) in the placebo group than the weight gain after an average of 6·8 months (∼3·3 kg) in the men on the testosterone programme, but not by 1·0 kg (1·0, −0·1) (P=0·06) or 3·3 kg (3·1, −3·5) (P=0·24). Similar articles: